The city's emergency calls converge in the melting pot on the Rhine and Neckar. The new emergency physician Dr. Nina Haddad at the Mannheim III fire station will now travel from call to call together with paramedic Paul Raue. Behind a supposedly life-threatening situation there often lies a moving human fate. The rest of the team consists of firefighter Markus Probst, fire chief Piotr Maszalek and Billy Johannes. Together with them, the doctor experiences many exciting and emotionally moving events.