Recently divorced surgeon Toby Fleishman plunges into the world of app-based dating and is more successful than he's ever been. When his ex-wife Rachel disappears, he is left with their children and has no idea where she is or if she ever plans to return. Balancing parenthood, friends, a much-anticipated promotion at the hospital, and all the suitable women Manhattan has to offer, he realizes he'll never be able to figure out what happened to Rachel until he learns the truth behind their marital problems.