Preacher tells the story of Jesse Custer, a conflicted pastor in a small Texas town. The town is inhabited by a mysterious entity that allows him to develop very unconventional powers. Jesse, his ex-girlfriend Tulip and an Irish vampire named Cassidy embark on a journey to find God...literally. However, they are pursued by the Saint of Killers, an immortal killing machine armed with a pair of supernatural Colt revolvers and the power to destroy an entire army.