Escape at Dannemora tells the true story of a prison break in upstate New York in the summer of 2015. Convicted murderer Richard Matt (Benicio del Toro) and fellow inmate David Sweat (Paul Daon) both have a sexual relationship with married jailer Tilly. Mitchell (Patricia Arquette). With Tilly's help, they manage to escape. What follows is a massive hunt for the two killers.