The young doctor Anne is the centerpiece of De Men van Dokter Anne. A week before she gets married, she catches her fiancé with someone else. Her world collapses and she returns to her parents, a professor of surgery and a meddling mother. Anne's father offers her a job in the hospital where he also works. At work, Anne is charming, selfless and highly professional, but her love life quickly turns into chaos. Her new chief physician, Dr. Marc Meijer, is not only an enormous macho, but also the unattainable love from her youth. Or does the mild-mannered gynecologist Dr. Sam Zwart have better cards? Who will she fall for?