Cha Jeong-suk is married to Seo In-ho. The latter works as a chief surgeon in a university hospital. He has a stern, sensitive and decisive personality. Jeong-suk has been a full-time housewife for the past 20 years, after giving up her career as a doctor during her medical school. After all these years, she decides to resume her training as a doctor and soon finds herself struggling to find her footing in a job full of surprises.