Diana Bishop, a historian and reluctant witch, unexpectedly discovers an enchanted manuscript in Oxford's Bodleian library. This discovery forces her back into the magical world, to unravel the secrets the book holds about magical creatures. She gets help from the mysterious geneticist and vampire, Matthew Clairmont. Despite a long-held mistrust between witches and vampires, they form an alliance and set out to protect the book and solve its hidden mysteries, while dodging threats from the creature world.