Bring Change to Mind is a mental health charity that was founded by Glenn Close after her sister was diagnosed with bipolar disorder. Their mission statement is "to end the stigma and discrimination surrounding mental illness."
The Robin Williams Legacy of Laughter Award was created in memory of the legendary comedian, who died by suicide in 2014.
Reynolds said he was "honoured" to receive the award.
"I am deeply and profoundly honoured. I mean, as somebody who - I not just watched Robin my whole life, but I've studied him... He's quite literally singular... There's nobody else like him before him or after him," the Deadpool star said at the event.
"There'll never will be. So, I'm incredibly honoured and touched to be here and also just to spend time with Mr. Williams' family... This is incredible.
"I would never compare myself to Robin Williams and as much as there was just something blowing through him that blew through no one else... You know his work lives on, but I can't think of a better legacy for Robin Williams..."
Williams is one of the most beloved comedy actors of all time, but he was also an acclaimed dramatic actor and won the Academy Award for Best Supporting Actor for his role in Good Will Hunting.
Still, Reynolds believes Williams' greatest legacy is who he was as a person.
"There's the body of work, there's the joy, and the laughter, they're left behind, but then there's... I think the greatest legacy of his is humanity, and I think that's why everyone's here today and tonight is to... celebrate that humanity," he continued.
Read more about the great work of Bring Change To Mind here.