London, 1851. The city is in the midst of the Industrial Revolution. Beneath the dirty red bricks and plumes of smoke are four young adventurous artists; the loyal William Holman Hunt, the naive John Millais, the rowdy Dante Gabriel Rossetti and the journalist Fred Walters. They are known as 'The Brotherhood'. Their quest for artistic immortality takes them to the darkest and funniest corners of the city. Sexy model Lizzie Siddal also joins them, but is she risking everything with this dangerous group?