Exactly 500 years after the death of Leonardo Da Vinci, Diederik van Vleuten travels after the world-famous genius. He goes to Leonardo's native village of Vinci, Florence, where Da Vinci became homo universalis, Milan, where he created the Vitruvian Man and his place of death at the French Court. Van Vleuten shows how Da Vinci changed the world with his inexhaustible curiosity and wonder. The journey takes Diederik along unique places and works such as The Last Supper and the world-famous Mona Lisa.