Four addicted people, Boaz, Daphni, Maarten and Mulu, are followed in their struggle with their 'greatest love': drugs and alcohol. This produces four personal stories, which provide the viewer with a penetrating picture of the complex world of alcohol and drug addiction, which leads to many vicious circles in the life of the addict. We follow these people from their urge to numb reality to their inner struggle, which produces confrontational moments. Will these people manage to break out of their impasse?