In The Devil's Whore we follow the adventures of the cunning Angelica Fanshawe. She makes clever use of the crisis the country is in to improve her own position. While England is ravaged by civil war, Angela turns against the English royal family when her childhood sweetheart and first husband, Harry Fanshawe, is executed. She is left completely destitute, and in her struggle for survival she even commits a murder. Luck smiles on her again when she meets Oliver Cromwell and marries his best friend, the heroic revolutionary Rainsborough, a man she adores. When Cromwell comes to power as Lord Protector, Angelica becomes his confidant. But when Cromwell kills her husband because he wants to remain Lord Protector, she is confronted by her behavior and must face the consequences.