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"Smell. Savor. Feel. Listen. Go. It could be your last time."
Santiago Mendoza is Mexico City's best crime photographer, but his profession has left him callous and incapable of affection towards his wife Marcela. One night, Santiago hears a distress call and despite the police's warnings, he infiltrates a disturbing crime scene. Shortly afterwards, he begins to suffer from a mysterious illness that causes him to lose his five senses one by one. Without knowing what is wrong with him or why, Santiago must find a solution to this condition before the world he knows disappears completely.