Young Beth Harmon was abandoned in the late 1950s and entrusted to an orphanage in Kentucky. She discovers an astonishing talent for chess as she becomes addicted to sedatives provided by the state to children. Haunted by her personal demons and fueled by a cocktail of narcotics and obsession, Beth turns into an impressively skilled and glamorous outcast as she is determined to conquer the traditional boundaries set in the male-dominated world of competitive chess.